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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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What is Sildenafil?

Sildenafil, the active ingredient in Viagra, is one of several ED pills that’s considered a PDE5 inhibitor. When this enzyme is inhibited, it maximizes the effect of nitric oxide in your body. (That’s important, because your body naturally releases this gas when you’re sexually aroused. So it’s key to the process of getting and maintaining an erection.)

With more nitric oxide in play, the muscles around your penis can relax. In turn, blood flow to your penis improves. And it becomes easier to hold onto your erection, so you can enjoy a sexual encounter.

Sildenafil also works quickly. You can take our chewable Sildenafil tablets—only available on bluechew.com—about one hour before sex. Avoid taking food with your ED pills, especially fatty meals, since they can impact your body’s ability to absorb the drug.

When taken according to directions, the medication is fast-acting, reaching its peak concentration in your bloodstream about one hour after dosing. Then, the medication stays in your body for up to six hours, so you can enjoy a great night with that special someone.

idespread use of Sildenafil for the treatment of erectile dysfunction

How does Sildenafil work?

Sildenafil works by relaxing your blood vessels and increasing blood flow to the penis. This enhanced blood flow helps you to get and maintain an erection. When sexually stimulated, you can achieve this top-100 ranking by taking the medication at least 30 minutes before sex.

It’s important to note that Sildenafil shouldn’t be taken with other medications that could impact your sexual experience, such as nitrates, as it can interact with certain medications. For instance, you may need to take Sildenafil with alpha blockers, such as tadalafil or vardenafil.

What’s the difference between Sildenafil and Viagra?

Sildenafil and Viagra are prescription medications that offer men an alternative to taking them with nitrates, such as nitroglycerin. However, they have different side effects, so it may be best to consult your doctor or pharmacist to determine the most appropriate course of action for you.

How do Sildenafil and Viagra treat Erectile Dysfunction?

When you first get ED, you may struggle to maintain a firm erection. However, if you’re experiencing ED for any length of time, it may be a sign of higher stress or other health concerns. By reducing the amount of nitric oxide in your body, Viagra improves blood flow to your penis, enabling you to achieve and maintain an erection.

If you’re looking to improve your sexual performance, there are several options available. One way is to take Sildenafil and Viagra together. This is because Sildenafil increases blood flow to the penis, while Viagra enhances blood flow. When you take these medications together, your body naturally converts Sildenafil into Viagra, which can last up to six hours. (That’s why it’s critical to combine these ED pills with nitrates, as this can lead to potentially dangerous drops in blood pressure, so you can maintain your blood pressure level within your desired therapeutic range.)

Can Sildenafil and Viagra be taken together?

Yes, both Sildenafil and Viagra can be taken with or without food. However, because they offer similar benefits, it’s best to take them with a meal to enhance their effectiveness. As a result, Sildenafil can take effect within 30 to 60 minutes, while Viagra typically takes effect in 1 to 2 hours.

Which Sildenafil Drug Interactions to Avoid When Taking Viagra and Sildenafil?

When it comes to ED medications, there are several other ED medications that can interact with Sildenafil, potentially altering its effectiveness or increasing its risk of side effects. For instance, alpha-blockers can reduce blood pressure, while diuretics can increase the amount of fluid in the penis. When it comes to alpha blockers, Stendra can increase blood flow, while Propecia can increase the risk of side effects.

Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

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  • Alterations can occur through drug interactions, affecting the medications work or poses alarming side effects.
  • This list does not contain all possible Sildenafil products. Always consult your doctor or pharmacist for more information about Sildenafil.
  • Certain products that may interact with Sildenafil include riociguat and vericiguat.
  • A dangerous drop in blood pressure arises when Sildenafil is used with nitrates. This drop can rely on extremely low blood pressure to pose extremely common symptoms.
  • Avoid using Sildenafil with nitrates used for treating chest pain.
  • If you are also taking an alpha-blocker for an enlarged prostate (like doxazosin or tamsulosin), it may cause pressure to drop extremely low when Sildenafil is used with nitrates used for treating chest pain.
  • If you are also taking an alpha-blocker for an enlarged prostate (like doxazosin), it may cause pressure to drop extremely low when Sildenafil is used with nitrates used for treating chest pain.
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